Casts

• 

  Chris Rock

  Osmosis Jones (voice)

• 

  Laurence Fishburne

  Thrax (voice)

• 

  David Hyde Pierce

  Drix (voice)

• 

  Brandy Norwood

  Leah (voice)

• 

  Elena Franklin

  Shane Detorre

• 

  Bill Murray

  Frank Detorre

• 

  William Shatner

  Mayor Phlegmming (voice)

• 

  Ron Howard

  Tom Colonic (voice)

• 

  Kid Rock

  Kidney Rock (voice)

• 

  Molly Shannon

  Mrs. Boyd

• 

  Chris Elliott

  Bob

• 

  Jonathan Adams

  Officer Tom (voice)

• 

  Carlos Alazraqui

  Spanish Germ (voice)

• Keith Anthony

  Additional Character Voices (voice)

• 

  Eddie Barth

  Conductor (voice)

• 

  Sally Brooks

  Additional Character Voices (voice)

• 

  Rodger Bumpass

  Joe Cramp / Announcer for Nerve News Network (voice)

• Michael Carven

  Additional Character Voices (voice)

• Paul Christie

  Dan Matter / Germ (voice)

• 

  Janis Dardaris

  Additional Character Voices (voice)

• Wendy Dillon

  Additional Character Voices (voice)

• 

  Antonio Fargas

  Chill the Flu Shot (voice)

• 

  Eddie Frierson

  Frank Police Department Officer (voice)

• 

  Donald Fullilove

  Doughnut (voice)

• 

  Jackie Gonneau

  Additional Character Voices (voice)

• Shannon Gregory

  Additional Character Voices (voice)

• 

  Richard Steven Horvitz

  Additional Character Voices (voice)

• 

  Rif Hutton

  Charlie (voice)

• Art Kimbro

  Additional Character Voices (voice)

• Joyce Kurtz

  Additional Character Voices (voice)

• 

  Anne Lockhart

  Female Red Blood Cell (voice)

• 

  Sherry Lynn

  Trudy (voice)

• 

  Danny Mann

  Musician Cell (voice)

• 

  Mickie McGowan

  Brain Librarian (voice)

• Kenny Olson

  Kidney Rock Band (voice)

• Jason Krause

  Kidney Rock Band (voice)

• Joe C.

  Kidney Rock Band (voice)

• Stefanie Eulinberg

  Kidney Rock Band (voice)

• Jimmie Bones

  Kidney Rock Band (voice)

• Uncle Kracker

  Kidney Rock Band (voice)

• 

  Joel Silver

  Police Chief (voice) (uncredited)

• David Ossman

  Scabies (voice) (uncredited)

• 

  John Melendez

  Artie (voice)

• 

  Héctor Mercado

  Additional Character Voices (voice)

• 

  Paul Pape

  Male Red Blood Cell #2 (voice)

• Marilyn Pasekoff

  Additional Character Voices (voice)

• 

  Chris Phillips

  Firefighter Doug (voice)

• Lynne Redding

  Additional Character Voices (voice)

• 

  Al Rodrigo

  Frank Police Department Walkie Talkie (voice)

• 

  Herschel Sparber

  Bruiser (voice)

• Doug Stone

  Police Officer Jamie (voice)

• Steve Susskind

  Mob Boss Germ (voice)

• 

  Keri Tombazian

  Additional Character Voices (voice)

• 

  Paul Tuerpe

  Additional Character Voices (voice)

• 

  Robert Wisdom

  Big Germ (voice)

• 

  Danny Murphy

  Zookeeper Superintendent

• Jack McCullough

  Zookeeper

• Will Dunn

  Oyster Boy

• 

  Jackie Flynn

  School Janitor

• Kelsey Jordan

  Bus Girl #1

• 

  Abe Farrelly

  Bus Girl #2

• Jesse Peter

  Laughing Boy

• John-Eliot Jordan

  Pea Soup Manager

• Nancy Byers

  Pea Soup Supervisor

• 

  Kevin J. Flynn

  Docky's Clamshack Waiter

• 

  Sean Gildea

  Dreamy Photographer

• Kathryn Frick

  Nurse #1

• 

  Nikki Tyler-Flynn

  Nurse #2

• Elizabeth Jordan

  Nurse #3

• 

  Zen Gesner

  ER Doctor #1

• Marc Hyman

  ER Doctor #2

• 

  Zak Penn

  ER Doctor #3

• Diane Conrad

  Zoo Visitor or Staff

• Judith Conrad

  Zoo Visitor or Staff

• Thomas Jordan

  The Zoo Visitor or Staff

• Sydney J. Bartholomew Jr.

  Zoo Visitor or Staff

• Erica Johnson

  Zoo Visitor or Staff

• Bo Cleary

  Pea Soup Staff

• Bruce McIntyre

  Pea Soup Staff

• Colleen O'Donnell

  Docky's Clamshack

• Docky

  The Bikini Gang

• Joe Murphy

  The Bikini Gang

• Brian Mone

  Police Officer

• Sean Fitzgerald

  Police Officer

• Grace Costa

  ER Nurse

• Emily O’Donnell

  School Girl